Effect of low-level laser therapy on bone regeneration during osseointegration and bone graft.

a person with a broken right leg can be seen walking on crutches in a living room

Randa Zein, Wayne Selting, and Stefano Benedicenti


Background: The effect of low-level laser therapy (LLLT) on bone regeneration during osseointegration and bone graft is very controversial. Despite many positive reports of in vitro and in vivo studies and more than 50 randomized clinical trials claiming a positive effect of photobiomodulation (PBM), many reports found no significant effect of lasers. 

Objective: The aim of this study was to evaluate studies correlating PBM and bone regeneration and to assesses parameters that produce positive results based on dose and output power used. 

Materials and methods: Four electronic databases were used: PubMed, Springer, Google Scholar, and Cochrane. 

Results: The research yielded 230 articles. The full texts of all articles were evaluated and scored using eligibility criteria adapted from Cericato et al. After evaluation, only 19 articles met the inclusion criteria. 

Conclusions: A positive effect of low-level laser energy on bone regeneration within a certain relationship between dose and output power was found. LLLT stimulates cellular metabolism, increasing protein synthesis and subsequent bone regeneration. A high dose combined with low power or a low dose combined with high power appears to produce a positive effect.

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