Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light

Reza Amid, Mahdi Kadkhodazadeh, Mitra Ghazizadeh Ahsaie, and Arian Hakakzadeh
Abstract:
The use of low-level laser (light) therapy (LLLT) has expanded in recent years into medical areas not traditionally associated with phototherapy, such as wound healing and inflammatory orthopedic conditions. One of the emerging applications is LLLT for muscle fatigue and muscle injury. Because mitochondria are recognized as the primary photoacceptors within cells—and muscle tissue is exceptionally rich in mitochondria—LLLT may offer substantial therapeutic benefits for muscle health.
LLLT can stimulate stem and progenitor cells, meaning that muscle satellite cells may respond positively and support enhanced tissue repair. Additionally, LLLT can reduce inflammation and oxidative stress, two major contributors to muscle fatigue and injury. This review summarizes preclinical animal studies and human clinical research evaluating LLLT's effects on muscle tissue. Athletes, individuals with muscle injuries, and patients with Duchenne muscular dystrophy may all benefit from this modality.
Key points:
- LLLT benefits muscle tissue due to its strong effects on mitochondrial activity and cellular signaling.
- The therapy activates satellite cells, reduces inflammation and oxidative stress, and enhances muscle repair.
- Evidence from both animal and human studies shows promising improvements in muscle performance and recovery.
Conclusion:
LLLT shows strong potential as a therapeutic tool for improving muscle performance, reducing fatigue, and accelerating muscle repair. It may serve athletes, rehabilitation patients, and individuals with muscle disorders as an effective adjunct therapy.
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