Photobiomodulation therapy (PBMT) in bone repair: a systematic review

by Jose Stalin Bayas Escudero, Maria Gabriela Benitez Perez, Marcelie Priscila de Oliveira Rosso, Daniela Vieira Buchaim, Karina Torres Pomini, Leila Maria Guissoni Campos, Mauro Audi, Rogério Leone Buchaim

Background: Photobiomodulation therapy (PBMT) using low-level laser influences the release of several growth factors involved in the formation of epithelial cells, fibroblasts, collagen and vascular proliferation, besides accelerating the synthesis of bone matrix due to the increased vascularization and lower inflammatory response, with significant increase of osteocytes in the irradiated bone. Considering its properties, beneficial effects and clinical relevance, the aim of this review was to analyze the scientific literature regarding the use of PBMT in the process of bone defect repair.

Conclusions: Many studies have shown that PBMT has positive photobiostimulatory effects on bone regeneration, accelerating its process regardless of parameters and the use of biomaterials. However, standardization of its use is still imperfect and should be better studied to allow correct application concerning the utilization protocols.