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Effect of photobiomodulation on alleviating primary dysmenorrhea caused by PGF
Qiqi Fu, Jiali Yang, Hui Jiang, Shangfei Lin, Haokuan Qin, Jie Zhao, Yanqing Wang, Muqing Liu
Abstract: Photobiomodulation (PBM) has attracted widespread attention in suppressing various pain and inflammation. Primary dysmenorrhea (PD) primarily occurs in adolescents and adult females, and the limited effectiveness and side effects of conventional treatments have highlighted the urgent need to develop and identify new adjunct therapeutic strategies. In this work, the results of pain and PGs demonstrated that 850 nm, 630 nm, and 460 nm all exhibited pain inhibition, decreased PGF2α and upregulated PGE2, while 630 nm PBM has better effectiveness. Then to explore the underlying biological mechanisms of red light PBM on PD, we irradiated prostaglandin-F2α induced HUSM cells and found that low-level irradiance can restore intracellular calcium ion, ROS, ATP, and MMP levels to normal levels. And, red light enhanced cell viability and promoted cell proliferation for normal HUSM cells. Therefore, this study proposes that red light PBM may be a promising approach for the future clinical treatment of PD.
Key points:
- Near-infrared photobiomodulation therapy (PBMT) reduces muscle soreness post-exercise by decreasing inflammatory markers and supporting faster recovery.
- PBMT enhances mitochondrial function by increasing ATP production and reducing oxidative stress, which helps restore muscle strength and function after intensive activity.
- Photobiomodulation therapy activates critical cellular pathways (reactive oxygen species, nitric oxide, and ATP synthesis), promoting anti-inflammatory and antioxidant responses essential for muscle recovery.
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Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy